Assist. Prof. Nontaya Nakkam

งานวิจัย (ย้อนหลัง 5 ปี 2019-2023)

นานาชาติ

  1. Kategeaw W, Nakkam N, Kiertiburanakul S, Sukasem C, Tassaneeyakul W, Chaiyakunapruk N. Cost-effectiveness analysis of HLA-B*13:01 screening for the prevention of co-trimoxazole-induced severe cutaneous adverse reactions among HIV-infected patients in Thailand. J Med Econ. 2023 Oct 13:1-17. doi: 10.1080/13696998.2023.2270868. Online ahead of print.
  2. Wattanachai P, Amornpinyo W, Konyoung P, Purimart D, Khunarkornsiri U, Pattanacheewapull O, Tassaneeyakul W, Nakkam N. Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions. Front Pharmacol. 2023 Sep 19;14:1248386. doi: 10.3389/fphar.2023.1248386. eCollection 2023.
  3. Nakkam N, Saksit N, Konyoung P, Amornpinyo W, Khunarkornsiri U, Purimart D, Pattanacheewapull O, Naewla T, Wattanachai P, Khaeso K, Chumworathayi P, Tassaneeyakul W. Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions. Drug Metab Pharmacokinet. 2022 Oct 18;47:100480. doi: 10.1016/j.dmpk.2022.100480. Epub ahead of print. PMID: 36379177.
  4. Chomean S, Nakkam N, Tassaneeyakul W, Attapong J, Kaset C. Development of label-free electrochemical impedance spectroscopy for the detection of HLA-B*15:02 and HLA-B*15:21 for the prevention of carbamazepine-induced Stevens-Johnson syndrome. Anal Biochem. 2022 Oct 1;658:114931. doi: 10.1016/j.ab.2022.114931. Epub ahead of print. PMID: 36191668.
  5. Khaeso K, Komvilaisak P, Chainansamit SO, Nakkam N, Suwannaying K, Kuwatjanakul P, Hikino K, Dornsena A, Kanjanawart S, Laoaroon N, Vannaprasaht S, Taketani T, Tassaneeyakul W. NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine. Drug Metabolism and Pharmacokinetics. 2022 Apr;43: 100436.
  6. Nakkam N, Konyoung P, Amornpinyo W, Saksit N, Tiamkao S, Khunarkornsiri U, Khaeso K, Pattanacheewapull O, Jorns TP, Chumworathayi P, Tassaneeyakul W. Genetic variants associated with severe cutaneous adverse reactions induced by carbamazepine. Br J Clin Pharmacol. 2022 Feb;88(2):773-786. doi: 10.1111/bcp.15022. Epub 2021 Aug 28. PMID: 34350628.
  7. Khaeso K, Udayachalerm S, Komvilaisak P, Chainansamit SO, Suwannaying K, Laoaroon N, Kuwatjanakul P, Nakkam N, Sukasem C, Puangpetch A, Tassaneeyakul W, Chaiyakunapruk N. Meta-Analysis of NUDT15 Genetic Polymorphism on Thiopurine-Induced Myelosuppression in Asian Populations. Front Pharmacol. 2021 Dec 2; 12: 784712.
  8. Nakkam N, Trubiano J, Gibson A, Phillips EJ. Considerations for cross-reactivity between vancomycin and other glycopeptides. J Allergy Clin Immunol Pract. 2021 Aug;9(8):3233. doi: 10.1016/j.jaip.2021.04.013. PMID: 34366100.
  9. Satapornpong P, Pratoomwun J, Rerknimitr P, Klaewsongkram J, Nakkam N, Rungrotmongkol T, Konyoung P, Saksit N, Mahakkanukrauh A, Amornpinyo W, Khunarkornsiri U, Tempark T, Wantavornprasert K, Jinda P, Koomdee N, Jantararoungtong T, Rerkpattanapipat T, Wang CW, Naisbitt D, Tassaneeyakul W, Ariyachaipanich M, Roonghiranwat T, Pirmohamed M, Chung WH, Sukasem C. HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients. Front Immunol. 2021 May 4;12:661135.
  10. Pratoomwun J, Thomson P, Jaruthamsophon K, Tiyasirichokchai R, Jinda P, Rerkpattanapipat T, Tassaneeyakul W, Nakkam N, Rerknimitr P, Klaewsongkram J, Srinoulprasert Y, Pirmohamed M, Naisbitt DJ, Sukasem C. Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01. Front Immunol. 2021 Apr 29;12:658593.
  11. Khaeso K, Nakkam N, Komwilaisak P, Wongmast P, Chainansamit SO, Dornsena A, Kanjanawart S, Vannaprasaht S, Tassaneeyakul W. Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients. J Pediatr Genet. 2021 Mar;10(1):29-34.
  12. Nakkam N, Gibson A, Mouhtouris E, Konvinse KC, Holmes NE, Chua KY, Deshpande P, Li D, Ostrov DA, Trubiano J, Phillips EJ. Cross-reactivity between vancomycin, teicoplanin, and telavancin in patients with HLA-A∗32:01–positive vancomycin-induced DRESS sharing an HLA class II haplotype. Journal of Allergy and Clinical Immunology. 2021 Jan;147(1):403-405.
  13. Wang CW*, Tassaneyakul W*, Chen CB, Chen WT, Teng YC, Huang CY, Sukasem C, Lu CW, Lee YS, Choon SE, Nakkam N, Chung-Yee Hui R, Huang YH, Chang YC, Yu-Wei Lin Y, Chang CJ, Chiu TM, Chantratita W, Konyoung P, Lee CN, Klaewsongkram J, Rerkpattanapipat T, Amornpinyo W, Saksit N, Rerknimitr P, Huei HY, Lin SH, Hsu CK, Fan WL, Chan CC, Lin YJ, Hung SI, Chung WH, Taiwan/Asian Severe Cutaneous Adverse Reaction Consortium. Whole Genome Sequencing Identifies Genetic Variants Associated with Co-trimoxazole Hypersensitivity in Asians. J Allergy Clin Immunol. 2020 Aug 10.
  14. *These authors contributed equally to this work.
  15. Areesinpitak T, Kanjanawart S, Nakkam N, Tassaneeyakul W, Vannaphasaht S. Prevalence of CYP2C19, CYP3A4 and FMO3 genetic polymorphisms in healthy northeastern Thai volunteers. ScienceAsia. 2020 August;46(4): 397-402.
  16. Sukasem C, Pratoomwun J, Satapornpong P, Klaewsongkram J, Rerkpattanapipat T, Rerknimitr P, Lertpichitkul P, Puangpetch A, Nakkam N, Konyoung P, Khunarkornsiri U, Disphanurat W, Srisuttiyakorn C, Pattanacheewapull O, Kanjanawart S, Kongpan T, Chumworathayi P, Saksit N, Bruminhent J, Tassaneeyakul W, Chantratita W, Pirmohamed M, Thai Severe Cutaneous Adverse Drug Reaction research g. Genetic association of co-trimoxazole-induced severe cutaneous adverse reactions is phenotype-specific: HLA class I genotypes and haplotypes. Clin Pharmacol Ther. 2020 May 26.
  17. Su SC, Chen CB, Chang WC, Wang CW, Fan WL, Lu LY, Nakamura R, Saito Y, Ueta M, Kinoshita S, Sukasem C, Yampayon K, Kijsanayotin P, Nakkam N, Saksit N, Tassaneeyakul W, Aihara M, Lin YJ, Chang CJ, Wu T, Hung SI, Chung WH. HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians. Clin Pharmacol Ther. 2019 Feb;105(2):476-485.

ระดับชาติ

  1. Konyoung P, Nakkam N, Khawsuk H, Khaeso K, Tassaneeyakul W. Severe Cutaneous Adverse Drug Reactions: A Study of 216 Patients from Udon Thani Hospital. Thai J Pharmacol. 2020 Jun 22;42(1):5-19.
  2. Kanyarat Khaeso, Nontaya Nakkam, Sirimas Kanjanawart, Suda Vannaprasaht, Patcharee Komvilaisak, Wichittra Tassaneeyakul. Pharmacogenetics of Thiopurine Drugs: Role of Thiopurine SMethyltransferase and Nucleoside Diphosphate-Linked Moiety X Motif 15 Genetic Polymorphisms on Drugs-induced Myelosuppression. Thai J Pharmacol 2019 June 13;41(No. 1):68-82.