งานวิจัย (ย้อนหลัง 5 ปี 2019-2023)

นานาชาติ

1. Oeurn K, Jusakul A, Jaidee R, Kukongviriyapan V, Senggunprai L, Prawan A, Kongpetch S. FGF10/FGFR2 Signaling: Therapeutically Targetable Vulnerability in Ligand-responsive Cholangiocarcinoma Cells. In Vivo. 2023 Jul-Aug;37(4):1628-1637.

2. Singdam P, Naowaboot J, Senggunprai L, Boonloh K, Hipkaeo W, Pannangpetch P. The Mechanisms of Neochlorogenic Acid (3-Caffeoylquinic Acid) in Improving glucose and Lipid Metabolism in Rats with Insulin Resistance Induced by A High Fat-High Fructose Diet. Trends in Sciences. 2023 Mar 1; 20(3): 6455.

3. Malikrong P, Prawan A,Kongpetch S, Senggunprai L. Momordin ic triggers mitochondria-mediated apoptosis of cholangiocarcinoma cells and enhances the efficacy of conventional chemotherapeutic drugs. Farmacia. 2023 Feb;71(3):518–525.

4. Butsri S, Kukongviriyapan V, Senggunprai L, Kongpetch S, Prawan A. 13‑cis‑retinoic acid inhibits the self‑renewal, migration, invasion and adhesion of cholangiocarcinoma cells. Int J Mol Med 2023; 51. Published online 2023 Jan 21.

5. Buranrat B, Senggunprai L, Prawan A, Kukongviriyapan V. Piperine Induces Cell Death, Apoptosis and Inhibits Migration in Cholangiocarcinoma Cells. Indian Journal of Pharmaceutical Education and Research. 2023 Jan-Mar; 57(1):161-166.

6. Kaewmeesri P, Pocasap P, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L. Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221124861.

7. Thongrung R, Senggunprai L, Hipkaeo W, Tangsucharit P, Pannangpetch P. Anti-angiogenesis and anti-inflammatory effects of Moringa oleifera leaf extract in the early stages of streptozotocin-induced diabetic nephropathy in rats. Asian Pacific Journal of Tropical Biomedicine. 2022 Jul 20;12(7):290-299.

8. Senggunprai L, Kukongviriyapan V, Prawan A, Kongpetch S. Epidermal growth factor receptor as a potential target of momordin Ic to promote apoptosis of cholangiocarcinoma cells. J Pharm Pharmacol . 2022 Jul 15;74(7):996-1005.

9. Butsri S, Kukongviriyapan V, Senggunprai L, Kongpetch S, Prawan A. All-trans-retinoic acid induces RARB-dependent apoptosis via ROS induction and enhances cisplatin sensitivity by NRF2 downregulation in cholangiocarcinoma cells. Oncol Lett. 2022 Jun;23(6):179.

10. Jaidee R, Kukongviriyapan V, Senggunprai L, Prawan A, Jusakul A, Laphanuwat P, Kongpetch S. Inhibition of FGFR2 enhances chemosensitivity to gemcitabine in cholangiocarcinoma through the AKT/mTOR and EMT signaling pathways. Life Sci. 2022 May 1; 296: 120427.

11. Buranrat B, Senggunprai L, Prawan A, Kukongviriyapan V. Effects of Simvastatin in Combination with Anticancer Drugs on Proliferation and Migration in Cholangiocarcinoma Cells. Indian J Pharm Sci 2022 Jan 17;84(1):72-79.

12. Laphanuwat P, Kongpetch S, Senggunprai L, Prawan A, Kukongviriyapan V. Licochalcone A Induces Cholangiocarcinoma Cell Death Via Suppression of Nrf2 and NF-kappaB Signaling Pathways. Asian Pac J Cancer Prev. 2022 Jan 1; 23: 115-123.

13. Wandee J, Srinontong P, Prawan A, Senggunprai L, Kongpetch S, Yenjai C, Kukongviriyapan V. Derrischalcone suppresses cholangiocarcinoma cells through targeting ROS-mediated mitochondrial cell death, Akt/mTOR, and FAK pathways. Naunyn Schmiedebergs Arch Pharmacol. 2021 Sep;394(9):1929-1940.

14. Phusrisom S, Senggunprai L, Prawan A, Kongpetch S, Kukongviriyapan U, Thawornchinsombut S, Siriamornpun S, Chumroenphat T, Changsri R, Kukongviriyapan V. Anti-tumor activity of rice bran hydrolysates on migration, invasion and angiogenesis. Asian Pacific Journal of Tropical Biomedicine. 2021 Jul 1; 11(7): 317-3261.

15. Kaewmeesri P, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L. Cucurbitacin B Diminishes Metastatic Behavior of Cholangiocarcinoma Cells by Suppressing Focal Adhesion Kinase. Asian Pac J Cancer Prev. 2021 Jan 1;22(1):219-225.

16. Klungsaeng S, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L. Targeted modulation of FAK/PI3K/PDK1/AKT and FAK/p53 pathways by cucurbitacin B for the antiproliferation effect against human cholangiocarcinoma cells. American Journal of Chinese Medicine. 2020 Sep 9; 48(6): 1475-1489.

17. Phusrisom S, Senggunprai L, Prawan A, Kongpetch S, Kukongviriyapan U, Thawornchinsombut S, Changsri R, Kukongviriyapan V. Rice bran hydrolysates induce immunomodulatory effects by suppression of chemotaxis, and modulation of cytokine release and cell-mediated cytotoxicity. Asian Pac J Trop Biomed 2020 Aug 17;10:470-8.

18. Jaidee R, Kongpetch S, Senggunprai L, Prawan A, Kukongviriyapan U, Kukongviriyapan V. Phenformin inhibits proliferation, invasion, and angiogenesis of cholangiocarcinoma cells via AMPK-mTOR and HIF-1A pathways. Naunyn Schmiedebergs Arch Pharmacol. 2020 May 7.

19. Buranrat B, Prawan A, Senggunprai L, Kukongviriyapan V. Inhibition of Growth and Migration of Cholangiocarcinoma Cells by Pamidronate. Experimental and Therapeutic Medicine. 2019 Nov; 18(5): 3977-3983.

20. Somparn N, Prawan A, Senggunprai L, Kukongviriyapan U, Jetsrisuparb A, Lee MH, Kim DH, Kukongviriyapan V, Surh YJ. Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in β-thalassemia/HbE patients. Free Radic Res. 2019 Jul;53(7):791-799.

21. Buranrat B, Prawan A, Senggunprai L, Kukongviriyapan V. Alendronate blocks human cholangiocarcinoma cell proliferation and migration. Tropical Journal of Pharmaceutical Research 2019 Jun;18(6):1179-1184.

22. Tusskorn O, Khunluck T, Prawan A, Senggunprai L, Kukongviriyapan V. Mitochondrial division inhibitor-1 potentiates cisplatin-induced apoptosis via the mitochondrial death pathway in cholangiocarcinoma cells. Biomed Pharmacother. 2019 Mar;111:109-118.

23. Klungsaeng S, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L. Cucurbitacin B induces mitochondrial-mediated apoptosis pathway in cholangiocarcinoma cells via suppressing focal adhesion kinase signaling. Naunyn Schmiedebergs Arch Pharmacol. 2019 Mar;392(3):271-278.

24. Wandee J, Prawan A, Senggunprai L, Kongpetch S, Kukongviriyapan V. Metformin sensitizes cholangiocarcinoma cell to cisplatin-induced cytotoxicity through oxidative stress mediated mitochondrial pathway. Life Sci. 2019 Jan 15;217:155-163.

25. Khunluck T, Kukongviriyapan V, Senggunprai L, Duangarsong W, Prawan A. The Inhibition Kinetics and Potential Anti-Migration Activity of NQO1 Inhibitory Coumarins on Cholangiocarcinoma Cells. Integr Cancer Ther. 2019 Jan-Dec;18:1534735418820444.

26. Tuponchai P, Kukongviriyapan V, Prawan A, Kongpetch S, Senggunprai L. Myricetin ameliorates cytokine-induced migration and invasion of cholangiocarcinoma cells via suppression of STAT3 pathway. J Cancer Res Ther. 2019 Jan-Mar;15(1):157-163.

27. Ponglong J, Senggunprai L, Tangsucharit P, Changsri R, Proongkhong T, Pannangpetch P. Ethanolic extract of Tubtim-Chumphae rice bran decreases insulin resistance and intrahepatic fat accumulation in high-fat-high-fructose diet fed rats. Asian journal of pharmaceutical and clinical research. 2019 Jan;12(1):506-511.

ระดับชาติ

1. Kaewmeesri P, Senggunprai L. Cancer Metastasis and Target for Treatment. Srinagarind Medical Journal. 2019 Apr;34(2):211-6.

2. Klungsaeng S, Senggunprai L. Protein Serine-Threonine Kinases as Drug Target In Cancer Treatment. Srinagarind Med J. 2020 Jul-Aug; 35(4): 488-495.

3. Jaidee R, Kongpetch S, Prawan A, Senggunprai L, Kukongviriyapan U, Kukongviriyapan V. Quercetin Enhances Phenformin in Inhibition of Cholangiocarcinoma Cell Growth. Srinagarind Med J. 2563 May-Jun;35(3):249-254.